Exploring protein domain evolution by designing new TPR-like domains [Elektronische Ressource] / von Manjunatha Karpenahalli Ranganathappa

Exploring protein domainevolution by designing newTPR-like domainsder Fakult at fur Biologieder Eberhard Karls Universit at Tubingenzur Erlangung des Grades einesDoktors der NaturwissenschaftenvonManjunatha Karpenahalli Ranganathappaaus Karpenahalli, IndienvorgelegteDissertation2006Tag der mundlic hen Prufung: 15.12.2006Dekan: Prof. Dr. Friedrich Sch o 1. Berichterstatter: Prof. Dr. Alfred Nordheim2. Berichterstatter: Prof. Dr. Andrei N. LupasDedicated in the memory of my father, the late Sri Ranganathappa.Acknowledgements I express my gratitude to Prof. Dr. Andrei Lupas, for sharing hisvast knowledge and skills in various areas of science, and for hisguidance throughout my PhD. I sincerely thank Dr. J org Martin whose expertise, understand-ing, and patience, added considerably to my graduate experience. I am very grateful to Prof. Dr. Alfred Nordheim for acceptingme as a PhD student at the University of Tubingen. Prof. Dr. S. Krishna Swamy is the one professor/teacher whotruly made a di erence in my life. It was under his tutelage thatI developed a focus and became interested in bioinformatics. A very special thanks to Dr. Ramadoss for helping me to strengthenmy skills in biochemistry. My special thanks to Ms. Karin Lehmann for her assistance andsupport during my stay in Germany.