Evolution and functional characterisation of uncoupling proteins in vertebrates [Elektronische Ressource] / vorgelegt von Martin Jastroch

Evolution and functional characterisation of uncoupling proteins in vertebrates Department of Animal Physiology Faculty of Biology Philipps-Universität MarburgDISSERTATIONzurErlangung des Doktorgrades der Naturwissenschaften (Dr. rer. nat.)dem Fachbereich vorgelegt von Martin Jastroch ausBerlinMarburg/ Lahn 2007Vom Fachbereich Biologie der Philipps-Universität Marburg als Dissertation am angenommen. Erstgutachter Zweitguachter Tag der mündlichen Prüfung CONTENTSCONTENTSGLOSSARY OF TERMS SUMMARY 1Introduction 1 Methods 9 Results and Discussion 16 References 30PUBLICATIONS and MANUSCRIPTS 35CHAPTER I “Uncoupling Protein 2 and 3 in Marsupials: Identification, 35Phylogeny and Gene Expression in Response to Cold and Fasting in Antechinus flavipes.” Jastroch M., Withers K.W., and Klingenspor M. Physiol Genomics 17, 130-139, 2004CHAPTER II “ A quest for the origin of three mammalian uncoupling 47proteins.” Jastroch M., Stoehr S., Withers K.W., and Klingenspor M. In Life in the cold: Evolution, Mechanisms, Adaptation, and Application, edited by Brian M. Barnes and Hannah V. Carey, pp. 417 – 426. 2004CHAPTER III “ Uncoupling protein 1 in fish uncovers an ancient 57evolutionary history of nonshivering thermogenesis.” Jastroch M., Wuertz S., Kloas W., and Klingenspor, M.