Evaluation of susceptibility genes for infammatory bowel disease by association study and candidate gene analyses [Elektronische Ressource] / vorgelegt von Weiyue Zheng

Evaluation of susceptibility genes for inflammatory bowel disease by association study and candidate gene analyses Dissertation zur Erlangung des Doktorgrades der Mathematisch-Naturwissenschaftlichen Fakultät der Christian-Albrechts-Universität zu Kiel vorgelegt von Weiyue Zheng M.sc Referent: Prof. Dr. h.c. Thomas C. G. Bosch Koreferent/in: …………………………………… Tag der mündlichen Prüfung: ............................................. Zum Druck genehmigt: Kiel, .............................................. Der Dekan Abbreviations and symbols ..............................................................................................................5 1. Introduction ..............................................................................................................................8 1.1 Inflammatory bowel disease...............................................................................................8 1.1.1 Basic concept on inflammatory disease ......................................................................8 1.1.1.1 Barrier organs.......................................................................................................8 1.1.1.2 Inflammation as a common response to environmental triggers..........................9 1.1.1.3 Bacterial flora on body surfaces as a disease factor....................................