Evaluation of IP-10 and {TNFα-transducing [TNF-alpha-transducing] parvoviral vectors as antitumoral agents in animal glioblastoma models [Elektronische Ressource] / presented by Marta Enderlin

Dissertation submitted to the Combined Faculties for the Natural Sciences and for Mathematics of the Ruperto-Carola University of Heidelberg, Germany for the degree of Doctor of Natural Sciences presented by Master of Science in Biotechnology Marta Enderlin born in G łogów, Poland Oral examination: Evaluation of IP-10 and TNFα-transducing parvoviral vectors as antitumoral agents in animal glioblastoma models Referees: Prof. Dr. Werner Buselmaier Prof. Dr. Lutz Gissmann To my husband Bernhard TABLE OF CONTENTS I Table of contents Summary……………………………………………………………………………………V Zusammenfassung………….…………………………………………………….………VI 1 Introduction...............................................................................................................1 1.1 Gliomas .............................................................................................................1 1.1.1 Molecular mechanisms involved in glioma development............................2 1.1.2 Glioma-directed therapy (standard therapies)............................................2 1.2 Gene Therapy ...................................................................................................4 1.2.1 Gene transfer-based immunotherapy.........................................................5 1.2.2 Enzyme/prodrug therapy.........................