Evaluation of cytokine transducing parvoviral vectors for glioma therapy [Elektronische Ressource] / presented by Elodie Kleinmann

Dissertation submitted to the Combined Faculties for the Natural Sciences and for Mathematics of the Ruperto-Carola University of Heidelberg, Germany for the degree of Doctor of Natural Sciences presented by Diplom-biotechnologin Elodie Kleinmann born in: Strasbourg, France ndOral-examination: March 2 2009 Evaluation of cytokine-transducing parvoviral vectors for glioma therapy Referees: Dr. Anne Régnier-Vigouroux Prof. Dr. Lutz Gissmann iv ACKNOLEDGMENTS ACKNOLEDGMENTS This thesis was performed in the group of Dr. Christiane Dinsart within the division of Tumor Virology and INSERM Unit U701 headed by Prof. Dr. Jean Rommelaere at the German Cancer Research Centre (DKFZ), Heidelberg. I would like to thank the following persons for their precious help and without whom this work would probably not have been possible: Prof. Dr. Jean Rommelaere for offering me the opportunity to complete my thesis in his division. Dr. Christiane Dinsart for the encouragement and guidance she provided me throughout this project and particularly for being so receptive when I enquired about the possibility of performing my thesis in her laboratory. I am very grateful for the many valuable discussions on various aspects of the work and other topics, as well as for her insightful and endless proofreading of this dissertation.