Estrogen synthesis and novel mechanisms of estrogen action in the developing brain [Elektronische Ressource] / Magdalena Karolczak

Abteilung Anatomie und ZellbiologieUniversität UlmLeiter: Prof. Dr. Dr. h.c. Ch. PilgrimEstrogen synthesis and novel mechanismsof estrogen action in the developing brainDissertationzur Erlangung des Doktorgrades der Humanbiologiean der Fakultät für Medizinder Universität Ulmvorgelegt vonDiplom-Biologin Magdalena Karolczakaus Torun, Polen2000Amtierender Dekan: Prof. Dr. med. P. Gierschik1. Gutachter: PD Dr. C. Beyer2. Gutachter: Prof. Dr. C. BruckerTag der Promotion: 04.05.2001Moim Rodzicom i BratuFor my Parents and my BrotherTable of contents:Abbreviations 11. Introduction 41.1. Estrogen and developing brain ……………………………………………… 41.2. en synthesis in the brain ……………………………………………… 61.2.1. Aromatase ………………………………………………………….………... 61.2.2. Aromatase gene structure …………………………………………………… 61.2.3. Aromatase in the brain ……………………………………………………… 71.2.4. Regulation of aromatase activity …………………………………………… 71.2.5. Sex differences in aromatase activity ………………………………………. 71.3. Estrogen signaling ………………………………………………….…….…. 81.3.1. Classical estrogen signaling ………………………………………………… 81.3.1.1. Structure and function of nuclear estrogen receptors-α and -β …….………. 81.3.1.2. Transcriptional properties of nuclear estrogen receptors …………………… 91.3.1.3. Localization of nuclear estrogen receptors in the brain …………….………. 111.3.2. Non-classical estrogen signaling ……………………………………………. 111.4. Aims and outlines of this thesis …………………………………….…….…. 132. Materials and methods 152.1.