Ensconsin, a Par-1 regulated microtubule associated protein, regulates kinesin dependent transport [Elektronische Ressource] / presented by Hsin-Ho Sung

Ensconsin, a Par-1 regulated microtubule associated protein, regulates kinesin dependent transport Hsin-Ho Sung 2007 Dissertation submitted to the Combined Faculties for the Natural Sciences and for Mathematics of the Ruperto-Carola University of Heidelberg, Germany for the degree of Doctor of Natural Sciences presented by Master of Science: Hsin-Ho Sung Born in Kaohsiung, Taiwan Oral-examination: 10.07.2007 Ensconsin, a Par-1 regulated microtubule associated protein, regulates kinesin dependent transport Referees: Dr. Anne Ephrussi Dr. Anne Regnier-Vigouroux 父親 之靈的 和在天 的母親 不辭辛苦僅此獻給 Summary Maternal proteins and mRNA contribute to both oocyte and embryo development. I performed a genetic screen to identify genes with maternal function in Drosophila. From this screen, I isolated PB4170, which affects CG14998 (ensconsin). The human homologue of this protein, E-MAP-115/Ensconsin, is known to be a microtubule binding protein that interacts dynamically with microtubules. However, its molecular function is poorly understood. From ensconsin mutant analysis in Drosophila, I have found that this gene is specifically required for microtubule-dependent polarity in the oocyte.