Endogenous opioid peptides in drug addiction [Elektronische Ressource] / submitted by Britta Schürmann

EndogenousopioidpeptidesindrugaddictionThesisSubmittedfora Doctoral Degree inNatural Sciences(Dr.rer.nat.)FacultyofMathematics andNaturalSciencesRheinischeFriedrich WilhelmsUniversity,BonnsubmittedbyBRITTA SCHÜRMANNBonnDecember2009Preparedwith the consentofthe Faculty ofMathematics andNatural SciencesRheinische Friedrich Wilhelms University,Bonn.This thesis is available online on HochschulschriftenserverofULB Bonnhttp://hss.ulb.uni-bonn.de/diss_online elektronisch publiziert.Publicationyear: 20101.Reviewer: Prof. Dr. rer. nat. Andreas Zimmer2.Reviewer: Prof. Dr. rer. nat. JörgHöfeldDate ofsubmission: 01/12/2009Date ofexamination: 14/03/2010Für H.-B. SchürmannAbbreviations5-HT 5-Hydroxytryptamine (serotonin)AAV Adeno-associatedvirusaca Anteriorcomissure,anteriorAcbC Nucleus acumbens,coreAcbShshellACTH AdrenocorticothropichormoneANOVA Analysis ofvarianceBlA BasolateralamygdalaBCIP 5-Bromo-4-chloro-3-indolylphosphateBCP 1-Bromo-3-chloro-propanecc Corpus callosumCDP-Star Chemiluminescentsubstrateforalkaline phosphataseCeA Central amygdalaCPu CaudateputamenCOGA Collaborativestudyonthegenetics ofalcoholismDAPI 4’,6-Diamidino-2-phenylindoleDEPC DiethylpyrocarbonateDIG DigoxigeninDMEM Dulbecco’s modifed Eagle’s mediumDMSO DimethylsulfoxideDNA DeoxyribonucleicacidDSM-IV Diagnosticandstatistical manualofmentaldisorders IVE.