Enantioselective biocatalysis for the preparation of optically pure tertiary alcohols [Elektronische Ressource] / vorgelegt von Giang Son Nguyen

Enantioselective biocatalysis for the preparation of optically pure tertiary alcohols Inauguraldissertation zur Erlangung des akademischen Grades doctor rerum naturalium (Dr. rer. nat.) an der Mathematisch-Naturwissenschaftlichen Fakultät der Ernst-Moritz-Arndt-Universität Greifswald vorgelegt von Giang Son Nguyen geboren am 10. September 1982 in Ho-Chi-Minh Stadt, Vietnam Greifswald, November 2010 Dekan: Prof. Dr. Klaus Fesser 1. Gutachter: Prof. Dr. Uwe Bornscheuer 2. Gutachter: Dr. Ulf Hanefeld Tag der Promotion: 08.12.2010 Table of contents 1. Introduction...........................................................................................................1 1.1. Scope and outline of this thesis..................................................................2 1.2. Enzymes as biocatalysts for sustainable chemistry....................................3 1.3. Tertiary alcohols in natural products and their roles as building blocks in organic chemistry........................................................................................4 1.3.1. Tertiary alcohols in natural products.......................................................4 1.3.2. Tertiary alcohols as building blocks in organic chemistry.......................5 1.4. Chemical synthesis of optically pure tertiary alcohols.................................6 1.5.