Electrostatic and non-electrostatic interactions of positively charged polypeptides with negatively charged lipid membranes [Elektronische Ressource] / von Christian Schwieger

Electrostatic and Non-Electrostatic Interactions of Positively Charged Polypeptides with Negatively Charged Lipid Membranes Dissertation zur Erlangung des akademischen Grades Doctor rerum naturalium (Dr. rer. nat.) vorgelegt der Naturwissenschaftlichen Fakultät II (Chemie und Physik) der Martin-Luther-Universität Halle-Wittenberg von Herrn Diplomchemiker Christian Schwieger geb. am 09. April 1976 in Halle (Saale) Gutachter: 1. Prof. Dr. rer. nat. Alfred Blume 2. Prof. Dr. rer. nat. Andreas Janshoff Tag der Verteidigung: 02. Feb. 2008 urn:nbn:de:gbv:3-000013374[http://nbn-resolving.de/urn/resolver.pl?urn=nbn%3Ade%3Agbv%3A3-000013374] to my parents I Contents 1 INTRODUCTION 1 1.1 Biological and model membranes............................................................................ 1 1.2 Lipid polymorphism ................................................................................................. 2 1.3 Motivation and aim of this work ............................................................................. 3 2 THE MODEL SYSTEM 5 2.1 The lipids ................................................................................................................... 5 2.2 The peptides............................................................................................................... 7 2.3 Membrane electrostatics .....................