Effects of the antimicrobial peptide LL-37 in combination with hyperthermic preconditioning on the outcome of septic rats [Elektronische Ressource] = Effekte des antimikrobiellen Peptids LL-37 in Kombination mit hyperthermer Präkonditionierung auf das outcome im Sepsismodell der Ratte / presented by Eugeniu Gurschi

From the Institute of Theoretical SurgeryProvisional Director: Univ. Prof. Dr. med. M. RothmundandFrom the Department of Anesthesia and Intensive CareDirector: Univ. Prof. Dr. med. Hinnerk WulfFaculty of Medicine of the Philipps University MarburgEffects of the antimicrobial peptide LL-37 in combinationwith hyperthermic preconditioning on the outcomeof septic rats„Effekte des antimikrobiellen Peptids LL-37 in Kombination mit hyperthermerPräkonditionierung auf das outcome imSepsismodell der Ratte“Inaugural-Dissertation toattain the degree “Doctor of Medicine”of the faculty of Human Medicine at the Philipps-UniversityMarburg, Germanypresented byEugeniu Gurschifrom Chi şin ău, MoldovaMarburg, 2008Accepted by the Faculty of Human Medicineof the Philipps-University Marburg 06.03.2008printed with permission of the FacultyDean: Prof. Dr. M. RothmundReferree: PD. Dr. rer. nat. A. BauhoferCo- referree: Prof. Dr. R. Schwarz2Dedicated to my dear wife Mariana3ContentContent1. Introduction 71.1.Epidemiology of sepsis 71.2.Definition of sepsis 91.3. The Immune System 121.3.1. Cytokines and sepsis 141.3.1.1. TNF – tumor necrosis factor 161.3.1.2. IL-6 – interleukin 6 161.3.1.3. IL-1 – interleukin 1 161.3.1.4. MIP-2 – macrophage inflammatory protein 171.3.2. Antimicrobial peptides 181.3.2.1. Mechanism of antimicrobial activity 181.3.2.2. LL-37/hCAP-18 – human antimicrobial peptide 211.3.2.3.