Effects of insulin sensitizing drug metformin on clinical features, endocrine and metabolic profiles in obese women with polycystic ovary syndrome [Elektronische Ressource] : a randomized, double blind, placebo-controlled sixteen weeks trial / von Elena Steinheim (geb. Ibragimova)

Aus der Klinik für Gynäkologie und Geburtshilfe der Medizinischen Fakultät der Charité - Universitätsmedizin Berlin DISSERTATION Effects of Insulin Sensitizing Drug Metformin on Clinical Features, Endocrine and Metabolic Profiles in Obese Women with Polycystic Ovary Syndrome: A Randomized, Double Blind, Placebo-Controlled Sixteen Weeks Trial Zur Erlangung des akademischen Grades Doctor medicinae (Dr. med.) vorgelegt der Medizinischen Fakultät der Charité – Universitätsmedizin Berlin von Elena Steinheim (geb. Ibragimova) aus Ufa Dekan: Prof. Dr. med. Martin Paul Gutachter: 1. Prof. Dr. med. W. Lichtenegger 2. Prof. Dr. med. H. Alexander 3. Priv-Doz. Dr. med. R. Sudik Datum der Promotion: 29.06.2006. 2 Inhaltsverzeichnis 1. INTRODUCTION ............................................................................................. 5 1.1. Polycystic Ovary Syndrome ......................................................................... 5 1.2. Presentation ................................................................................................. 5 1.3. Polycystic Ovaries........................................................................................ 7 1.4. Pathogenesis Of PCOS................................................................................ 7 1.5. Long-Term Disease Risks ..............................................................