Effects of ceramide on cardiomyoblasts viability and mitochondrial function [Elektronische Ressource] / von Amir Mohmed Ahmed Abushouk

Aus dem Institut für Pathophysiologie An der Martin-Luther Universität Halle-Wittenberg (Direktor: Prof. Dr.med. Jürgen Holtz) Effects of ceramide on cardiomyoblasts viability and mitochondrial function Dissertation zur Erlangung des akademischen Grades Doktor der Medizin (Dr.med.) vorgelegt der Medizinischen Fakultät der Martin-Luther Universität Halle-Wittenberg Von Amir Mohmed Ahmed Abushouk Geboren am 26.07.1969 in Eldain, Sudan Betreuer: Junior Prof. Dr. med. S. Rohrbach Gutachter: 1. Frau Jun.-Prof. Dr. S. Rohrbach 2. Frau Prof. Dr. U. Müller-Werdan 3. Prof. Dr. H. Morawietz (Dresden) 21.09.2006Verteidigungsdatum: 21.02.2007urn:nbn:de:gbv:3-000011724[http://nbn-resolving.de/urn/resolver.pl?urn=nbn%3Ade%3Agbv%3A3-000011724]Abstract and bibliographic description: Ceramides are sphingolipids that have been shown to regulate several cellular processes including differentiation, growth suppression, cell senescence, and apoptosis. Accumulation of ceramides in aging hearts may play a role in the proapoptotic shifting of Bcl-x splicing and thus accelerates cell death as well as the aging process. This study was undertaken to investigate the effects of ceramides on the viability of the cardiomyoblast cells (H9C2), the type of cell death that may result from ceramides treatment, whether they affect the balance of the pro and antiapoptotic Bcl-2 family members and mitochondrial function.