Effects of a carbohydrate restricted diet on the metabolic state and progressive pancreatic beta-cell loss in transgenic mice expressing a dominant negative GIP receptor [Elektronische Ressource] / by Martina Christine Höfer

From the Institute of Veterinary Pathology Department of General Pathology and Pathological Anatomy Chair: Prof. Dr. W. Hermanns Ludwig-Maximilians-University Munich Under the supervision of Prof. Dr. R. Wanke Effects of a carbohydrate restricted diet on the metabolic state and progressive pancreatic beta-cell loss in transgenic mice expressing a dominant negative GIP receptor Inaugural - Dissertation to achieve the doctor title of veterinary medicine at the Faculty of Veterinary Medicine of the Ludwig-Maximilians-University, Munich by Martina Christine Höfer from Munich Munich 2006 Gedruckt mit Genehmigung der Tierärztlichen Fakultät der Ludwig-Maximilians-Universität München Dekan: Univ.-Prof. Dr. E. P. Märtlbauer Referent: Prof. Dr. Wanke Korreferent: Prof. Dr. Gabius Tag der Promotion: 09. Februar 2007 Für meine Eltern Table of content - I - 1. Introduction........................................................................................................... 1 2. Literature review................................................................................................... 3 2.1 Diabetes mellitus ............................................................................................ 3 2.1.1 Definition and description of diabetes mellitus............................................ 3 2.1.2 Classification of human diabetes mellitus.........