Dynamics of cell packing and polar order in developing epithelia [Elektronische Ressource] / vorgelegt von Reza Farhadifar

Institutfu¨rTheoretischePhysikFakulta¨t Mathematikund NaturwissenschaftenTechnischeUniversita¨tDresdenDynamicsofCellPackingandPolarOrderinDeveloping EpitheliaDissertationzur ErlangungdesakademischenGradesDoctor rerumnaturaliumvorgelegtvonRezaFarhadifargeborenam24. Mai 1982in Mashhad,IranDresden 2009Eingereicht am 26.03.20091. Gutachter: Prof Dr Frank Jülicher2. Gutachter: Prof Dr Karsten Kruse3. Gutachter: Prof Dr Jens-Uwe SommerVerteidigt am 25.05.2009AbstractDuring development, organs with different shape and functionality form from asingle fertilized egg cell. Mechanisms that control shape, size and morphology oftissues pose challenges for developmental biology. These mechanisms are tightlycontrolled by an underlying signaling system by which cells communicate to eachother. However, these signaling networks can affect tissue size and morphologythrough limited processes such as cell proliferation, cell death and cell shape changes,which are controlled by cell mechanics and cell adhesion. One example of such asignaling system is the network of interacting proteins that control planar polariza-tion of cells. These proteins distribute asymmetrically within cells and their distri-bution in each cell determines of the polarity of the neighboring cells. These pro-teins control the pattern of hairs in the adult Drosophila wing as well as hexagonalrepacking of wing cells during development.