Dynamic system analysis of receptor interaction and effectuation mechanisms of digoxin in the rat heart [Elektronische Ressource] / von Myoungki Baek

Dynamic System Analysis of Receptor Interaction and Effectuation Mechanisms of Digoxin in the Rat Heart Dissertation Zur Erlangung des akademischen Grades doctor rerum naturalium (Dr. rer. nat) vorgelegt der Mathematisch-Naturwissenschaftlich-Technischen Fakultät der Martin-Luther-Universität Halle-Wittenberg von Myoungki Baek, MS. geb. 02. 09. 1970 in Daejon, Südkorea Gutachter: 1. Prof. Dr. Michael Weiss 2. Prof. Dr. Reinhard Neubert 3. Prof. Dr. Richard Süverkrüp Halle (Saale), den 06. 04. 2005 urn:nbn:de:gbv:3-000008190[http://nbn-resolving.de/urn/resolver.pl?urn=nbn%3Ade%3Agbv%3A3-000008190] Table of Contents 1. Introduction 1.1 Cardiac glycosides ························································································· 1 1.2 Physiology of cardiac muscle ········································································· 4 1.3 Inotropic response of cardiac glycosides ······················································· 6 + + 1.3.1 Inhibition of Na ,K -ATPase ································································ 6 + 2+ 1.3.2 Role of Na /Ca Exchanger ································································· 7 1.4 Disease states ································································································· 101.