Dynamic modeling of the JAK2-STAT5 signal transduction pathway to dissect the specific roles of negative feedback regulators [Elektronische Ressource] / presented by Julie Bachmann

Dissertation submitted to the Combined Faculties for the Natural Sciences and for Mathematics of the Ruperto-Carola University of Heidelberg, Germany for the degree of Doctor of Natural Sciences presented by Diplom-Biochemikerin Julie Bachmann born in Mainz, Germany oral examination: ………………. Dynamic Modeling of the JAK2/STAT5 Signal Transduction Pathway to Dissect the Specific Roles of Negative Feedback Regulators Referees: PD Dr. Ursula Klingmüller Prof. Dr. Michael Brunner Acknowledgements Acknowledgements Many thanks to all the people who supported me during my work. First of all, I would like to thank my supervisor PD Dr. Ursula Klingmüller for giving me the opportunity to work on this exciting interdisciplinary project and for her advice and guidance. I thank Prof. Dr. Michael Brunner for being the second referee for this thesis. I am grateful to all current and former members of our group for their continuous support, for the nice atmosphere and the stimulating working environment. I would like to thank Dr. Marcel Schilling for his computational support and fruitful discussions on mathematical modeling, Dr. Verena Becker for the joint work and scientific contributions as well as Ute Baumann and Sandra Manthey for all the technical help provided. I thank Dr. Andrea C. Pfeifer for advice as a member of my PhD committee and Dr.