Drug delivery to the bone-implant interface [Elektronische Ressource] : functional hydroxyapatite surfaces and particles / presented by Andrea Schüssele

Drug delivery to the bone-implant interface: Functional hydroxyapatite surfaces and particles Dissertation to obtain the Degree of Doctor of Natural Sciences (Dr. rer. nat.) from the Faculty of Chemistry and Pharmacy of the University of Regensburg Presented by Andrea Schüssele from Waldkirch-Buchholz 2006 Promotionsgesuch eingereicht am: 31.08.2006 Die Arbeit wurde angeleitet von: Prof. Dr. A. Göpferich Mündliche Prüfung am: 02.11.2006 Prüfungsausschuss: Prof. Dr. S. Elz Prof. Dr. A. Göpferich Prof. Dr. G. Franz Prof. Dr. N. Korber Table of contents Chapter 1 Introduction and Goals of the Thesis ………,……………………………………………........………1 Chapter 2 Surface modifications of Hydroxyapatite ceramics to modulate cell adhesion and improve tissue generation……………..…………...………………...23 Chapter 3 Labeling of lysozyme and BMP-2 with 125 Iodine for the characterization of surface modification methods…………….........….....……35 Chapter 4 Adsorption and immobilization of lysozyme on PEGylated HA ceramic surfaces ………………………………..…………………..……….......53 Chapter 5 A novel method for protein immobilization on HA ceramic surfaces using bisphosphonates …………………………………………………………..……..