Drug delivery of oligonucleotides at the blood brain barrier [Elektronische Ressource] : a therapeutic strategy for inflammatory diseases of the central nervous system / Berit Osburg

From the Institute of Normal and Pathological Physiology Philipps-University Marburg Faculty of Medicine Germany Director: Prof. Dr. Dr. J. Daut in collaboration with School of Pharmacy, Texas Tech University Health Sciences Center, Department of Pharmaceutical Sciences, Amarillo, Texas, U.S.A. Dean: A. A. Nelson, R.Ph., Ph.D. Drug Delivery of Oligonucleotides at the Blood-Brain Barrier: a Therapeutic Strategy for Inflammatory Diseases of the Central Nervous System Inaugural-Dissertation for attaining the degree of Doctor of Human Biology (Dr. rer. physiol.) submitted to the Faculty of Medicine Philipps University Marburg Berit Osburg of Erfurt/Germany Marburg 2003 Accepted by the Faculty of Medicine, Philipps University Marburg on May 27, 2003 Printed with the Faculty’s permission Dean: Prof. Dr. B. Maisch Referent: Prof. Dr. K. Voigt Co-referent: Prof. Dr. K. Heeg To Uli and Jördis Table of Contents Page 1. Introduction 1 1.1. Drug delivery strategies through the blood-brain barrier 1 1.1.1. Small molecules 3 1.1.2. Carrier-mediated transport of drugs 3 1.1.3. Nanoparticles and Liposomes 4 1.1.4. Peptide-based neuropharmaceuticals 5 1.1.5. Antisense drugs 5 1.2.