Development of universal transmembrane transporter systems [Elektronische Ressource] / presented by Markus Andreas Moosmeier

DISSERTATION submitted to the Combined Faculties for the Natural Sciences and for Mathematics of the Ruperto-Carola-University Heidelberg, Germany, for the degree of Doctor of Natural Sciences presented by Markus Andreas Moosmeier, M.Sc. born in Landshut, Germany Date of oral examination: 2009/07/23 DEVELOPMENT OF UNIVERSAL TRANSMEMBRANE TRANSPORTER SYSTEMS Referees: Professor Dr. Stephan Urban Professor Dr. Hanswalter Zentgraf To my parents and Andrea, for their endless love and encouragement. “In the beginning, I looked around and could not find quite the protein I dreamed of. So I decided to build it myself.” Freely adapted from Dr. Ing. h.c. Ferdinand Porsche Table of Contents SUMMARY ................................................................................................................................................ 1 PUBLICATIONS AND PATENTS.............................................................................................................. 9 CHAPTER 1: INTRODUCTION............................................................................................................... 13 1.1 Targeted Therapy ......................................................................................................................... 13 1.2 Transmembrane Delivery of Therapeutic Agents .........................................