Development of a polymeric planar microwell device (pMALDI chip) for enhancing protein analysis in combination with MALDI-TOF,MS instrumentation [Elektronische Ressource] / von Alfredo Jesus Ibanez Gabilondo

Development of a polymeric planar microwell device (pMALDI chip) for enhancing protein analysis in combination with MALDI-TOF/MS instrumentation Dissertation zur Erlangung des akademischen Grades doctor rerum naturalium (Dr. rer. nat) vorgelegt dem Rat der Biologisch-Pharmazeutischen Fakultät der Friedrich-Schiller-Universität Jena von M.Sc. Alfredo Jesús Ibáñez Gabilondo Geboren am 23.08.1977 in Lima, Perú Referees (Gutachtern): 1. Prof. Dr. Hans-Peter Saluz Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute Cell and Molecular Biology department head Beutenbergstr. 11a, 07745 Jena Thueringen, Germany 2. Prof. Dr. Karl Otto Greulich Leibniz Institute for Age Research - Fritz Lipmann Institute (FLI) Single cell and single molecule techniques research group head Beutenbergstr. 11, 07745 Jena Thueringen, Germany 3. Prof. Dr. Michael Koehler Technical University Ilmenau Faculty of Mathematics and Natural Sciences Department of Physical Chemistry and Microreaction Technology Weimarer Str. 32, 98693 Ilmenau Thueringen, Germany thDate of Oral Examination: January 9 2008 thDate of Public Defense: February 26 2008 iiAlfredo J. Ibáñez Index Table of Contents 1. Introduction 1 1.