Development of a new class of potent and selective non-steroidal inhibitors of {17β-hydroxysteroid [17-beta-hydroxysteroid] dehydrogenase type 1 [Elektronische Ressource] : bis(hydroxyphenyl)substituted azoles, thiophenes, benzenes and aza-benzenes / von Emmanuel Bey

Development of a New Class of Potent and Selective Non-Steroidal Inhibitors of 17 -Hydroxysteroid Dehydrogenase Type 1 Bis(hydroxyphenyl)substituted Azoles, Thiophenes, Benzenes and Aza-Benzenes Dissertation zur Erlangung des Grades des Doktors der Naturwissenschaften der Naturwissenschaftlich-Technischen Fakultät III Chemie, Pharmazie, Bio- und Werkstoffwissenschaften der Universität des Saarlandes von Diplom-Chemiker Emmanuel Bey Saarbrücken 2008b - I - Tag des Kolloquiums: 29 Januar 2009 Dekan: Prof. Dr. U. Müller Berichterstatter: Prof. Dr. R.W. Hartmann Prof. Dr. U. Kazmaier - II - Diese Arbeit entstand unter der Anleitung von Prof. Dr. R.W. Hartmann in der Fachrichtung 8.2 Pharmazeutische und Medizinische Chemie der Naturwissenschaftlich-Technischen Fakultät III der Universität des Saarlandes von Juli 2004 bis November 2007. - III - Acknowledgements I would like to express my sincere gratitude to my supervisor Prof. Dr. Rolf W. Hartmann, for introducing me in the field of medicinal chemistry, and for giving me the opportunity to prepare my thesis as a member of his research group. His support and advice have been a great help during these years. I would like to thank my official referee Prof. Dr. Uli Kazmaier for the reviewing of this dissertation. I am deeply grateful to Dr.