Development and validation of capillary electrophoresis assays for the determination of the stereochemical purity of drug substances [Elektronische Ressource] / Sudaporn Wongwan. Gutachter: Gerhard K. E. Scriba ; Ulrike Holzgrabe ; Andreas Seeling

Development and validation of capillary electrophoresis assays for thedetermination of the stereochemical purity of drug substancesDissertationZur Erlangung des akademischen Gradesdoctor rerum naturalium(Dr. rer. nat.)vorgelegt dem Rat der Biologisch-Pharmazeutischen Fakultätder Friedrich-Schiller-Universität Jenavon Master of Pharmacy Program in Pharmaceutical SciencesSudaporn Wongwangeboren am 17.01.1978 in Loei, ThailandGutachter1. Prof. Dr. Gerhard K. E. Scriba, Jena2. Prof. Dr. Ulrike Holzgrabe, Würzburg3. P.D. Dr. Andreas Seeling, JenaTag der öffenlichen Verteidigung: 11 February 2011iTable of ContentsChapter I: Introduction.......................................................................................................................... 11.1 Enantiomer and its importance..................................... 11.1.1 Definitions and overview of isomes....................... 11.1.2 Enantiomers and biological activities..................................................................................... 21.1.3 Enantiomers and drug development...................... 31.2 Enantiomeric purity and regulatory agencies................ 51.3 Separation and determination of enantiomeric impurity in drug substances................................ 61.4 Capillary electrophoresis............................................................................................................... 91.4.1 Capillary zone electrophoresis (CZE)....................