Development and formulation of carbomer 934P containing mucoadhesive pellets by fluid bed techniques [Elektronische Ressource] / vorgelegt von Im-Jak Jeon

Development and Formulation of Carbomer 934P-containing Mucoadhesive pellets by Fluid-bed Techniques Von der Naturwissenschaftlichen Fakultät I- Biowissenschaften Institut für Pharmazie der Martin-Luther-Universität Halle-Wittenberg genehmigte Dissertation zur Erlangung des akademischen Grades Doctor rerum naturalium (Dr. rer. nat.) vorgelegt von Frau Im-Jak Jeon geb. am: 27.04.1974 in: Munkyung, Korea Gutachter 1. Prof. Dr. Dr. Reinhard Neubert 2. Prof. Dr. Wolfgang Süß 3. Prof. Dr. Peter Kleinebudde Tag der Verteidigung: 27. August 2007 urn:nbn:de:gbv:3-000012267[http://nbn-resolving.de/urn/resolver.pl?urn=nbn%3Ade%3Agbv%3A3-000012267]TABLE OF CONTENTS Table of contents I V Abbreviations index 1. Introduction and Objectives 1 1.1 Introduction 1 1.2 Objectives 2 2. Theoretical overview 4 2.1 Basics of bioadhesion 4 2.1.1 Advantages and applications of bioadhesive dosage forms 4 2.1.2 Bioadhesive polymers 5 2.2 Theory of granule formation 6 2.2.1 Methods of granulation 6 2.2.2 Fluid-bed granulation 7 2.2.2.1 System description 7 2.2.2.2 Variables in the fluid-bed granulation process 8 2.3 Dry-coating technique 11 2.3.1 Concept and advantages 11 2.3.2 Applications of dry particle coating 12 2.3.3 Dry-coating by fluid-bed coater 12 2.3.3.1 System description 13 2.3.3.2 Procedures 13 2.3.3.3 Important process parameters 14 3.