Development and characterization of poly(vinyl acetate) based oral dosage forms [Elektronische Ressource] / von Sandra Strübing

Development and characterization of poly(vinyl acetate) based oral dosage forms Dissertation zur Erlangung des akademischen Grades doctor rerum naturalium (Dr. rer. nat.) vorgelegt der Naturwissenschaftlichen Fakultät I der Martin-Luther-Universität Halle-Wittenberg von Sandra Strübing geboren am 20.10.1977 in Waren (Müritz) Gutachter: 1. Prof. Dr. Karsten Mäder 2. Prof. Dr. Dr. h.c. Reinhard Neubert 3. Prof. Dr. Jürgen Siepmann urn:nbn:de:gbv:3-000014858 [http://nbn-resolving.de/urn/resolver.pl?urn=nbn%3Ade%3Agbv%3A3-000014858] Halle, den 02. Oktober 2008 Contents 1 Introduction 1 2 Thermal analysis of polymer films 11 2.1 Introduction 11 2.2 Materials 13 2.3 Methods 13 2.3.1 Preparation of free films 13 2.3.2 Thermal mechanical analysis experiments 14 2.3.3 Differential scanning calorimetry experiments 14 2.4 Results and discussion 15 2.4.1 Thermal mechanical analysis experiments 15 2.4.2 Differential scanning calorimetry experiments 15 2.5 Conclusion 18 3 Mechanistic analysis of drug release 19 3.1 Introduction 19 3.2 Materials 21 3.3 Methods 21 3.3.1 Preparation of tablet cores 21 3.3.2 Film Coating of tablet cores 22 3.3.3 Determination of dissolution characteristics 23 3.3.