Development and applications of neutral models for evolution of gene [Elektronische Ressource] / vorgelegt von Michael Roßkopf

Development and Applications of NeutralModels for Evolution of Gene ExpressionInaugural – DissertationzurErlangung des Doktorgrades derMathematisch-Naturwissenschaftlichen Fakult atder Heinrich-Heine-Universit at Dusseldorfvorgelegt vonMichael Ro kopfaus BochumMai 2007Aus dem Institut fur Bioinformatikder Heinrich-Heine-Universit at DusseldorfGedruckt mit der Genehmigung der Mathematisch-NaturwissenschaftlichenFakult at der Heinrich-Heine-Universitat Dusse ldorfReferent: Prof. Dr. Arndt von HaeselerKorreferent: Prof. Dr. Michael LeuschelTag der mundlic hen Prufung: 22.06.2007AcknowledgmentsFirst and foremost, I wish to thank my supervisor Arndt von Haeseler for his excellentadvise, collaborations, and his friendly behaviour. I want to thank Gunter Weiss for theidea for this thesis and the mentoring in the rst year of my PhD studies. Also I wanttothankMichaelLeuschelforacceptingthetasktoreadthisthesisasasecondreviewer.I thank Ralf Kronenwett from the University Hospital Dusse ldorf for the close collabora-tion and the medical data sets. I want to thank Philipp Khaitovich, Michael Lachmann,Wolfgang Enard, Ines Hellmann, and Svante P aa bo for the primate data sets, fruitfuldiscussions,andnewimpulsesduringmyvisitsattheMax-PlanckInstituteforEvolution-ary Anthropology in Leipzig. Furthermore, I thank Chris Voolstra from the Universityof Cologne for discussions and his mice data sets.