Detection of NADPH oxidase subunits NOX1 and NOX4 in lung adenocarcinoma A549 cells, and impact of NOX1 on Nrf2- and HIF-1-dependent gene regulation [Elektronische Ressource] / by Malec, Viktor

Detection of NADPH oxidase subunits NOX1 and NOX4 in lung adenocarcinoma A549 cells, and impact of NOX1 on Nrf2- and HIF-1- dependent gene regulation Inaugural Dissertation submitted to the Faculty of Medicine in partial fulfillment of the requirements for the PhD-Degree of the Faculties of Veterinary Medicine and Medicine of the Justus Liebig University Giessen by Malec, Viktor born in Liberec, Czech Republic Giessen 2010 From the Department of Internal Medicine II Director: Prof. Dr. Werner Seeger of the Faculty of Medicine of the Justus Liebig University Giessen First Supervisor and Committee Member: PD Dr. Jörg Hänze Second Supervisor and Committee Member: Prof. Dr. Thomas Kietzmann Committee Members: Prof. Dr. Ernst Petzinger Prof. Dr. Andre Menke thDate of Doctoral Defense: 30 March 2010 Table of content I. Table of content……………………………………………………………….1 II. List of figures…………………………………………………….……………4 III. Table of abbreviations…………………………………………………………6 I. Table of content 1. Introduction................................................................................................................. 9 1.1 NADPH oxidase........................................................................................................ 9 1.1.