Design and synthesis of antisense peptide nucleic acid conjugated MR contrast agents [Elektronische Ressource] = Design und Synthese von Antisense-Peptid-Nukleinsäure-konjugierten MR-Kontrastmitteln / vorgelegt von Wu Su

Design and Synthesis of Antisense Peptide Nucleic Acid Conjugated MR Contrast Agents Design und Synthese von Antisense Peptid-Nukleinsäure konjugierten MR Kontrastmitteln DISSERTATION der Fakultät für Chemie und Pharmazie der Eberhard-Karls-Universität Tübingen zur Erlangung des Grades eines Doktors der Naturwissenschaften 2007 vorgelegt von Wu Su Tag der mündlichen Prüfung 26. Oktober 2007 Dekan Prof. Dr. Lars Wesemann 1. Berichterstatter Prof. Dr. K. Albert 2. Berichterstatter Prof. Dr. K.-H. Wiesmüller Acknowledgements The work described in this thesis is a result from the collaboration between the department of High-Field Magnetic Resonance Center at the Max Planck Institute for Biological Cybernetics, under the supervision of Prof. Dr. Kamil Ugurbil, and the Institute for Organic Chemistry at Eberhard-Karls University of Tuebingen, under the supervision of Prof. Dr. Klaus Albert and Prof. Dr. Karl-Heinz Wiesmüller. First of all, I would like to thank all of my three supervisors for their excellent guidance during my PhD period in Tuebingen. Prof. Dr. Kamil Ugurbil provided the opportunity, funding and intellectual support for my PhD study. Prof.