Cystine-import and regulation of apoptosis in B-lymphocytes [Elektronische Ressource] / Ana Banjac

A thesis submitted of the requirements for the degree of Doctorate (Dr. rer. nat) from the Faculty of Biology at the Ludwig-Maximilians-University, Munich, Germany: Cystine-Import and Regulation of Apoptosis in B-Lymphocytes Ana Banjac GSF Research Centre for Environment and Health GmbH Institute for Clinical Molecular Biology and Tumor Genetics, Munich, Germany Munich, November 2005 First Examiner: Prof. Dr. Dirk Eick Second Examiner: PD Dr. Angelika Böttger Date of the oral examination: Munich 08.11.2005 Contents Contents: LIST OF ABBREVIATIONS..........................................................................................1 INTRODUCTION...........................................................................................................3 1.1 Oxygen Radicals and Antioxidative Defense System .................................................. 3 1.2 Burkitt Lymphoma Cells and Oxidative Stress........................................................... 6 1.3 The Heterodimeric Amino Acid Transporters ............................................................ 9 1.3.1 The Heavy Chains rbAT and 4F2hc....................................................................... 10 1.3.2 The Light Chains ...........................................................................................