Constitutive activation of Jak2-STAT5-signalling pathway in MedB-1 cells due to deficient SOCS-1 [Elektronische Ressource] / submitted by Alexandra Juliana Bucur

Institute for Pathology and Forensic Medicine Department of Pathology Director: Prof. Dr. med. P. Möller Constitutive Activation of Jak2/STAT5- Signalling Pathway in MedB-1 cells Due to Deficient SOCS-1 Dissertation for obtaining the Doctor Degree of Human Biology at the Faculty of Medicine, University of Ulm submitted by: ALEXANDRA JULIANA BUCUR from Cluj-Napoca, Romania ULM, 2005 Amtierender Dekan: Prof. Dr. med. K.-M. Debatin Erstgutachter: Prof. Dr. med. P. Möller Zweitgutachter: Prof. Dr. med. T. Seufferlein Tag der Promotion: 28.10.2005 TABLE OF CONTENTS 3 TABLE OF CONTENTS TABLE OF CONTENTS .................................................................................................. 3 ABBREVIATIONS ........................................................................................................... 6 1. INTRODUCTION ......................................................................................................... 8 1.1 Supressors of Cytokine Signaling (SOCS)................................................................. 8 1.1.1 Molecular Mechanisms of SOCS action.....