Conformational changes in DNA and MutS during mismatch repair in Escherichia coli, analyzed by fluorescence spectroscopy [Elektronische Ressource] / vorgelegt von Michele Cristóvão

Conformational changes in DNA and MutS during mismatch repair in Escherichia coli, analyzed by fluorescence spectroscopy Inauguraldissertation zur Erlangung des Grades Doktor der Naturwissenschaften Dr. rer. nat. Des Fachbereiches Biologie und Chemie der Justus-Liebig Universität Vorgelegt von M. Sc. Michele Cristóvão Gießen, 2009 The present study has been carried out at the Institute of Biochemistry, Justus-Liebig University Giessen, between March 2006 and March 2009, under the supervision of Prof. Dr. Peter Friedhoff and Prof. Dr. Alfred Pingoud. Dean Prof. Dr. P. Schreiner Institut für Organische Chemie Justus-Liebig-Universität Heinrich-Buff-Ring 58 35392 Giessen Advisor Prof. Dr. Peter Friedhoff Institut für Biochemie Justus-Liebig-Universität Heinrich-Buff-Ring 58 35392 Giessen Co-advisor Dr. Mark Szczelkun Department of Biochemistry School of Medical Sciences University Walk Bristol BS8 1TD, UK Acknowledgements I would like to thank: Prof. Dr. Alfred Pingoud, for giving me the opportunity to work in his lab, for the constructive critics and suggestions. Prof. Dr, Peter Friedhoff, my supervisor, for his guidance, amazing patience, motivation, insightful discussions, interest and availability. Dr. George Silva, G.