Concepts to interfere with protein-protein complex formations [Elektronische Ressource] : data analysis, structural evidence and strategies for finding small molecule modulators / vorgelegt von Peter Block

CONCEPTS TO INTERFERE WITH PROTEIN-PROTEIN COMPLEX FORMATIONS: DATA ANALYSIS, STRUCTURAL EVIDENCE AND STRATEGIES FOR FINDING SMALL MOLECULE MODULATORSDISSERTATIONZURERLANGUNG DES DOKTORGRADESDER NATURWISSENSCHAFTEN(DR. RER. NAT.)demFachbereich Pharmazie derPHILIPPS-UNIVERSITÄT MARBURG vorgelegt vonPeter Blockaus Bergisch GladbachMarburg an der Lahn, im November 2005Vom Fachbereich Pharmazie der PHILIPPS-UNIVERSITÄT MARBURG als Dissertation angenommen am: 15.12.2005Erstgutachter: Prof. Dr. G. KlebeZweitgutachter: Prof. Dr. E. HüllermeierTag der mündlichen Prüfung: 16.12.2005I would like to express my gratitude to PROF. DR. GERHARD KLEBE for being a patient supervisor and for supporting this work with ideas, criticism, and encouragement. PROF. DR. EYKE HÜLLERMEIER for collaboration in the EPIC project and guidance in the field of Machine Learning. DR. CHRISTOPH SOTRIFFER for helpful discussions and hints during the entire PhD and for the very accurate reviewing of the manuscript. The teamwork in the development of AFFINDB was outstanding. JURI PÄRN for the enjoyable collaboration in the EPIC project. the group of PROF. DR. ALFRED WITTINGHOFER, namely DR. ALEXANDER WOLF, DR. CHRISTIAN JELICH-OTTMANN and DR. MICHAEL WEYAND for the collaboration in the 14-3-3 project and their never-ending patience with the in vitro testing of compounds.