Computational lipidology [Elektronische Ressource] : prediction of lipoprotein density profiles in human blood plasma / von Katrin Hübner

Computational LipidologyPrediction of Lipoprotein Density Profiles in Human BloodPlasmaDISSERTATIONzur Erlangung des akademischen Gradesdoctor rerum naturalium(Dr. rer. nat.)im Fach Biologieeingereicht an derMathematisch-Naturwissenschaftlichen Fakultät Ider Humboldt-Universität zu BerlinvonFrau Dipl.-Biochem. Katrin Hübnergeboren am 09.02.1975 in BerlinPräsident der Humboldt-Universität zu Berlin:Prof. Dr. Christoph MarkschiesDekan der Mathematisch-Naturwissenschaftlichen Fakultät I:Prof. Dr. Lutz-Helmut SchönGutachter:1. Prof. Dr. Jens-Georg Reich2. Prof. Dr. Hermann-Georg Holzhütter3. Prof. Dr. Ulrike Beisiegeleingereicht am: 17. Dezember 2007Tag der mündlichen Prüfung: 6. Mai 2008AbstractMonitoring the major lipoprotein classes, particularly low-density lipopro-teins (’bad’ LDL) and high-density lipoproteins (’good’ HDL) for charac-terizing risk of cardiovascular disease (CVD) is well-accepted and routinein clinical practice. However, it is only one-half of the truth as lipoproteinclasses comprise non-homogeneous populations of lipoprotein particles vary-ing significantly in their composition of lipids and apolipoproteins. Variousstudies have shown differing metabolic behavior and contribution to CVDof individual lipoprotein sub-populations.