Computational analysis of gene regulatory networks [Elektronische Ressource] / von Hendrik Hache

Computational Analysis of GeneRegulatory NetworksD I S S E R T A T I O Nzur Erlangung des akademischen Gradesd o c t o r r e r u m n a t u r a l i u m(Dr. rer. nat.)im Fach Biophysikeingereicht an derMathematisch-Naturwissenschaftlichen Fakultät IHumboldt-Universität zu BerlinvonHERRN DIPL.-PHYS. HENDRIK HACHEgeboren am 21. April 1977 in BerlinPräsident der Humboldt-Universität zu BerlinProf. Dr. Dr. h.c. Christoph MarkschiesDekan der Mathematisch-Naturwissenschaftlichen Fakultät IProf. Dr. Lutz-Helmut SchönGutachter:1. Prof. Dr. Edda Klipp, Humboldt-Universität zu Berlin2. Prof. Dr. Hans Lehrach, Max-Planck-Institut für Molekulare Genetik3. Prof. Dr. Joachim Selbig, Universität PotsdamEingereicht am: 22. Juni 2009Tag der mündlichen Prüfung: 03. November 2009iiAbstractGene regulation, the coordinated control of gene expression, is accomplishedmainly by the interplay of multiple transcription factors. This gives rise tohighly complex and cell-type specific, interwoven structures of regulatory in-teractions summarized in gene regulatory networks. Computational analysisof gene regulatory networks can be classified in forward modeling approachesand reverse engineering methods. The goal ofd is the pre-diction of gene expression dynamics based on gene regulatory networks andperturbations thereof. Such forward modeling approaches need comprehen-sive information on network structure, kinetic laws, and kinetic parameters.