Comparative translational, transcriptional, and functional profiling of clear cell and papillary renal cell carcinoma [Elektronische Ressource] / written by Julia Diegmann

COMPARATIVE TRANSLATIONAL, TRANSCRIPTIONAL, AND FUNCTIONAL PROFILING OF CLEAR CELL AND PAPILLARY RENAL CELL CARCINOMA Academic Dissertation (Doctor rerum naturalium) at the Faculty of Biology of the Friedrich-Schiller University, Jena, Germany Written by Certified Biologist Julia Diegmann born 20th of February, 1977 in Fulda Gutachter: 1. PD Dr. von Eggeling 2. Prof. Dr. Pool-Zobel 3. Prof. Dr. Hartmann Tag der mündlichen Prüfung: 21.07.2006 Tag der öffentlichen Verteidigung: 06.11.2006 Mit dem Wissen wächst der Zweifel. Johann Wolfgang von Goethe Outline 1 Abstract ..........................................................................................................1 2 Introduction.....................................................................................................2 2.1 Expression Profiling and Marker Gene Discovery.........................................................2 2.2 Renal Cell Carcinoma .........................................................................................4 2.2.1 Pathological Classification of Renal Cell Carcinoma ..............................................4 2.2.2 Marker Genes and Pathways in Renal Cell Carcinoma ............................................5 2.2.3 Immune Escape Mechanisms of Renal Cell Carcinoma ............................................