Comparative genomics and phylogenetics of the vertebrate CYP3 family [Elektronische Ressource] / Huan Qiu

Comparative genomics and phylogenetics of the vertebrate CYP3 family Dissertation Zur Erlangung des Grades “Doktor der Naturwissenschaften” Am Fachbereich Biologie der Johannes Gutenberg-Univerisität in Mainz Huan Qiu aus Jiangxi, China Mainz 2008 Table of contents i Table of contents 1. Introduction ................................................................................................................... 1 1. 1 The Cytochrome P450 superfamily ......................................................................... 1 1.2 Human CYP3A family.............................................................................................. 2 1.2.1 Structure of human CYP3A genes and locus ...................................................... 2 1.2.2 Substrates of human CYP3A............................................................................. 5 1.2.3 Variability in the expression of human CYP3A.................................................. 6 1.2.4 Nuclear receptors and CYP3A regulation........................................................... 7 1.2.5 Regulatory DNA elements in CYP3A promoters................................................ 9 1.3 CYP3 evolution...................................................................................................... 11 1.4 Objectives of this study............