Cognitive deficits and their underlying structural and functional alterations in mice selectively bred for high stress reactivity [Elektronische Ressource] / Alana Knapman

Cognitive Deficits and their Underlying Structural and Functional Alterations in Mice Selectively Bred for High Stress Reactivity Alana Knapman Dissertation Faculty of Biology Ludwig Maximilian University, Munich Cognitive Deficits and their Underlying Structural and Functional Alterations in Mice Selectively Bred for High Stress Reactivity Dissertation Faculty of Biology Ludwig Maximilian University Munich Alana Knapman Msc rdborn 23 June 1979 in Landvetter, Sweden Munich, 2010 Supervisor: Dr. Chadi Touma 1. Examiner: Prof. Dr. Rainer Landgraf 2. Examiner: Prof. Dr. Lutz Wiegrebe Examination date: 14.12.2010 “Intellect is in itself a mode of exaggeration, and destroys the harmony of any face.” Oscar Wilde Content 5 CONTENT CONTENT 5 ABBREVIATIONS 7 LIST OF PUBLICATIONS 10 SUMARY 1 AIMS OF THE THESIS 13 INTRODUCTION 14 MAJOR DEPRESSION…………………………………………………………...14 Symptoms of Major Depression………………………………………………..14 Subtypes of Major Depression…………………………………………………15 Treatment of Major Depression………………………………………………..16 SCHIZOPHRENIA……………………………………………...………………….16 Symptoms of Schizophrenia……………………………………………………17 Treatment of Schizophrenia…………………………………………………….17 SIMILARITIES BETWEEN MAJOR DEPRESSION AND SCHIZOPHRENIA…………………………………………………………..