Clcn2 polymorphisms in Africans from an endemic malaria area [Elektronische Ressource] / vorgelegt von Jochen Paul

Aus dem Institut für Physiologie der Universität Tübingen Abteilung Physiologie I Abteilungsleiter: Professor Dr. F. Lang Clcn2 polymorphisms in Africans from an endemic malaria area Inaugural-Dissertation zur Erlangung des Doktorgrades der Medizin der Medizinischen Fakultät der Eberhard Karls Universität zu Tübingen vorgelegt von Jochen Paul aus Friedrichshafen 2006 Dekan: Professor Dr. I. B. Autenrieth 1. Berichterstatter: Privatdozent Dr. S. M. Huber 2. Berichterstatter: Professor P. Kremsner 1 2 Contents: 1 Introduction ................................................................................... 1 1.1 Malaria..........................1 1.1.1 Life cycle..................3 1.1.2 Clinical symptoms.....................................................................4 1.2 Infected erythrocytes.....5 1.2.1 New permeability pathways .......................................................5 1.2.2 PSAC – plasmodial erythrocyte surface anion.............................6 channel .....................................................6 1.2.3 Infection-Induced Outwardly Rectifying Anion ..........................7 Channels...................................................7 1.2.4 Alterations of the Host Erythrocyte Volume ...............................9 1.2.5 ClC-2 Channels in Plasmodium-infected .................................