Circulating concentrations of cytokines as markers for pathogenic processes in type 1 diabetes and their association with {β-cell [beta-cell] function, {β-cell [beta-cell] stress and metabolic status [Elektronische Ressource] / vorgelegt von Christian Pfleger

Circulating concentrations of cytokines as markers for pathogenic processes in type 1 diabetes and their association with ß-cell function, ß-cell stress and metabolic status Inaugural-Dissertation zur Erlangung des Doktorgrades der Mathematisch-Naturwissenschaftlichen Fakultät der Heinrich-Heine-Universität Düsseldorf vorgelegt von Christian Pfleger aus Düsseldorf Mai 2008 Gedruckt mit der Genehmigung der Mathematisch-Naturwissenschaftlichen Fakultät der Heinrich-Heine-Universität Düsseldorf Referent: PD. Dr. N.C. Schloot Korreferent: Prof. Dr. M. Kassack to Leonie, Maya and Lilu Contents List of abbreviations II Chapter 1 1 Introduction Chapter 2 29 Effect of serum content and diluent selection on assay sensitivity and signal intensity in multiplex bead-based immunoassays J Immunol Methods. 2008 Jan 1;329(1-2):214-8 Chapter 3 39 Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes Clin Immunol. 2008 Apr 21. (Epub ahead of print) Chapter 4 61 Association of IL-1ra and adiponectin with C-peptide and remission in patients with type 1 diabetes Diabetes.