Chromosome 6q deletion in precursor T-cell lymphoblastic lymphoma and leukemia of childhood and adolescence [Elektronische Ressource] / by Burkhardt, Birgit

Chromosome 6q deletion in precursor T-cell lymphoblastic lymphoma and leukemia of childhood and adolescence Inaugural Dissertation submitted to the Faculty of Medicine in partial fulfillment of the requirements for the PhD-Degree of the Faculties of Veterinary Medicine and Medicine of the Justus Liebig University Giessen by Burkhardt, Birgit of Stuttgart Giessen 2006 2 From the Center of Pediatrics Department of Pediatric Hematology and Oncology Head: Professor Dr. Alfred Reiter of the Faculty of Medicine of the Justus Liebig University Giessen First Supervisor and Committee Member: Prof. Dr. Alfred Reiter Second Supervisor and Committee Member: Prof. Dr. Martin Stanulla M. Sc. Committee Members: Prof. Dr. Dr. Hans Michael Piper Prof. Dr. Rainer Renkawitz Date of Doctoral Defense: 16.02.2007 3 To Dorothea Neubert and Holger Burkhardt 4 Table of content 1 Summary (English/German) .......................................................................................10 2 Introduction .................................................................................................................12 2.1 T-cell maturation .........................................................................................................12 2.2 Lymphoblastic lymphoma .....................................................................