Chemopreventive potential of Se-enriched broccoli and kale sprouts in vitro and in a human prostate cancer xenograft model [Elektronische Ressource] / vorgelegt von Jung-Hyun Kim

Chemopreventive potential of Se-enriched broccoli and kale sprouts in vitro and in a human prostate cancer xenograft model German Cancer Research Center, Heidelberg (Division of Epigenomics and Cancer Risk Factor) University of Heidelberg (Biology) DISSERTATION Inaugural-Dissertation zur Erlangung der Doktorwürde der Ruprecht-Karls-Universität Heidelberg 2010 vorgelegt von Jung-Hyun KIM 1 2 Presented by Jung-Hyun KIM References: Prof. Dr. Thomas Rausch Prof. Dr. Bernard Watzl 3 4 Jesus Christ ―A man's heart deviseth his way: but the LORD directeth his steps‖ KING JAMES (PROVERBS 16:9)5 6 TABLE OF CONTENTS I. TABLE OF CONTENTS I TABLE OF CONTENTS ........................................................................................................ 7 II. LIST OF ABBREVIATIONS ............................. 11 1. INTRODUCTION ............................................................................................................... 13 1.1 Prostate cancer................ 13 1.1.1 Prostate cancer incidence ......................................................................................... 13 1.1.2 Multistep process of prostate carcinogenesis .......................... 13 1.1.