Chemokine receptor CCR7 deficiency prevents tolerance induction in a murine heart transplantation model [Elektronische Ressource] / submitted by Xiaosun Liu

Institute of Immunology, Hannover Medical School Hannover, Germany Chemokine receptor CCR7 deficiency prevents tolerance induction in a murine heart transplantation model Thesis for the Degree of Medical Doctor Hannover Medical School Submitted by Xiaosun Liu From Hangzhou PR China, 2008 Angenommen vom Senat der Medizinischen Hochschule Hannover am 10. 12. 2008 Gedruckt mit Genehmigung der Medizinischen Hochschule Hannover Präsident: Prof. Dr. Dieter Bitter-Suermann Betreuer: Prof. Dr. med. Reinhold Förster Referent: Prof. Dr. med. Georg Behrens Korreferent: Prof. Dr. med. Bernhard Schieffer Tag der mündlichen Prüfung: 10. 12. 2008 Promotionsausschussmitglieder: Prof. Dr. Hans Dieter Tröger Prof. Dr. Klaus Resch Prof. Dr. Reinhard Schwinzer TABLE OF CONTENTS TABLE OF CONTENTS Abbreviations...............................................................................................4 1. Introduction................................................................................................6 1.1 T cell and transplant immunology...............................................................7 1.2 Role of secondary lymphoid organs in transplant immunology..................9 1.3 Donor specific transfusion together with costimulation blockade treatment induces transplant tolerance........................................................