Chemical organizations in natural reaction networks [Elektronische Ressource] / von Florian Centler

Chemical Organizations in NaturalReaction NetworksDissertation zur Erlangung des akademischen Grades doctor rerumnaturalium (Dr. rer. nat.) vorgelegt dem Rat der Fakult¨at fur¨Mathematik und Informatik der Friedrich-Schiller-Universit¨at Jenavon Dipl.-Systemwiss. Florian Centler,geboren am 14.11.1975 in DortmundGutachter:1. PD Dr. Peter Dittrich2. Prof. Dr. Stefan Schuster3. Ao. Univ. Prof. Dr. Christoph FlammTag der letzten Prufung¨ des Rigorosums: 11.09.2008Tag der ¨offentlichen Verteidigung: 15.09.2008To my loving parents.AcknowledgementsThis thesis owes its existence to the help and support of numerouspeople. Foremost, I am deeply indebted to my supervisorPeter Dittrich.I am grateful to:Clemens Beckstein,Christoph Flamm,Gerd Grunert¨ ,Christoph Kaleta,Ralph Lehmann,Naoki Matsumaru,Hari Nair,Stefan Schuster,Pietro Speroni di Fenizio, andKlaus-Peter Zauner.AbstractA living cell consists of a tremendous number of components thatinteract in complicated ways sustaining the processes of life. Knowl-edge of the inner workings of such systems is commonly portrayedas networks on different levels: gene regulatory networks, metabolicnetworks, and signal transduction networks. With the advent of thenew field “systems biology”, whole cell models come into reach thatintegrate these different networks and further cellular processes.