Characterization of the ROS production in ischemia-reperfusion-induced lung injury [Elektronische Ressource] / by Akylbek Sydykov

Characterization of the ROS Production in Ischemia/Reperfusion-induced Lung Injury Inaugural Dissertation submitted to the Faculty of Medicine in partial fulfilment of the requirements for the PhD-Degree of the Faculties of Veterinary Medicine and Medicine of the Justus Liebig University Giessen by Akylbek Sydykov of Osh, Kyrgyz Republic Giessen 2009 From the Medical Clinic II, University of Giessen Lung Centre Chairman: Werner Seeger, Prof., M.D. of the Faculty of Medicine of the Justus Liebig University Giessen First Supervisor and Committee Member: Prof. Dr. Ardeschir Ghofrani Second Supervisor and Committee Member: Prof. David B. Pearse, MD Committee Member (Chair): Prof. Dr. Wolfgang Kummer Committee Member: Prof. Dr. Joachim Roth thDate of Doctoral Defence: 27 of October, 2009 Index of contents Index of contents Index of contents……………………………………………………………………………...i Index of tables……………………………………………………………………………….iv Index of figures…………………………………………………………………………….....v 1. Introduction…………………………………………………………………...……….1 1.1.Pathophysiology of ischemia/reperfusion lung injury.……………....….………………..1 1.1.1. Definitions……………………………………….……………….…….……………..1 1.1.2. Organ ischemia…………………..………….…….….….…………………………...2 1.1.3. Reperfusion of the ischemic organ…………………….….