Characterization of the protein phosphatase 1E (PPM1E) [Elektronische Ressource] : localisation and truncation in brain tissue and effects on neuronal morphology in primary neuronal culture / submitted by Anne Lene Jessen

Characterization of the protein phosphatase 1E (PPM1E) Localization and truncation in brain tissue and effects on neuronal morphology in primary neuronal culture Dissertation in partial fulfillment of the requirements for the degree “Doctor rerum naturalium” at the Georg August University Göttingen, Faculty of Biology submitted by Anne Lene Jessen born in Kiel, Germany Göttingen 2010 First Referee: Prof. Dr. Nils Brose Second Referee: Prof.em. Dr. Rüdiger Hardeland Advisor: Dr. Heinz von der Kammer Date of submission of the PhD thesis: September 21, 2010 Date of thesis defence: November 2, 2010 2 Declaration This dissertation has been written independently and with no other sources and aids than quoted. I hereby declare that this submission is my own work and that, to the best of my knowledge and belief, it contains no materials previously published or written by another person nor material which to a substantial extent has been accepted for the award of any other degree of the university or other institute of higher education, except where due acknowledgement has been made in the text. Anne Lene Jessen Göttingen, September 21, 2010 3 TABLE OF CONTENTS TABLE OF CONTENTS ABSTRACT..................................................................................................................