Characterization of leukotriene D_1tn4-induced gene signatures in human endothelial cells [Elektronische Ressource] / von Barbara Uzonyi

Characterization of leukotriene D -induced gene s ignatures in 4human endot helial cel lsDissertationzur Erlangung de s akadem ischen Grades doctor rerum naturalium(Dr. rer. nat.)vorgelegt dem Rat der Biologi sch-P harm azeutischen Fakultätder Friedrich-Schiller-U niversität Jenavon Barbara Uzonyigeboren am 23.01.1979 i n Buda pestGutachter:1.P rofessor Dr. A ndreas J. R. H abenicht (Jena)2.P rofessor Dr. Re inhard Wetzker (J ena)3.P rofessor Dr. H artm ut Kühn (Berlin)Tag de r Doktorprüfung: 09.03.2007Tag de r öffentlichen Verteidigung: 21.05.2007Table of contentsIntroduction.................................................................................................................................61.1. L eukotrienes and t heir receptors........................................................................................61.1.1. L T biosynthesis...........................................................................................................61.1.2. P hysiologi cal and pathologi cal rol e of t he LTs..........................................................91.1.3. L T receptors................................................................................................................91.1.3.1. BL T-Rs..............................................................................................................101.1.3.2. Cys LT-Rs101.1.3.3. F unctional studies on c ysLT-Rs...............................................................