Characterization of differential Toll-like receptor function in human immune cells and association with susceptibility to recurrent HSV-1 reactivations and gastric cancer [Elektronische Ressource] / Chin-An Yang. Gutachter: Hans-Dieter Volk ; Günther Schönrich ; Ralf Reiner Schumann

Characterization of differential Toll-like receptor function in human immune cells and association with susceptibility to recurrent HSV-1 reactivations and gastric cancer Dissertation Zur Erlangung des akademischen Grades doctor rerum naturalium (Dr. rer. nat) Im Fach Biologie eingericht an der Mathematisch-Naturwissenschaftlichen Fakultät I der Humboldt– Universität zu Berlin von Chin-An Yang, MD Präsident der Humboldt-Universität zu Berlin Prof. Dr. Dr. h.c. Christoph Markschies Dekan der Fakultät Prof. Dr. Andreas Herrmann Gutachter: 1. Prof. Dr. Hans-Dieter Volk 2. Prof. Dr. Günther Schönrich 3. Prof. Dr. Ralf Reiner Schumann Datum der Promotion: 20. 01. 2011 Table of contents Summary ...................................................................................................................6 Zusammenfassung...................................................................................................7 Abbreviations............................................................................................................8 1 Introduction..................................................................................................9 1.1 Overview of Toll-like receptors.........................................................................9 1.1.1 Toll-like receptors and viral infections....................................................9 1.1.1.1 TLR 1, 2, 4, 6 .......................................