Characterization of cellular prion protein (PrPC) in Caenorhabditis elegans [Elektronische Ressource] / Marcel Werner Stahl

University Hospital of Ulm Department of Neurology Head of department: Prof. Dr. med. Albert Christian Ludolph Characterization of cellular prion Cprotein (PrP ) in Caenorhabditis elegans Dissertation zur Erlangung des Doktorgrades der Medizin (Dr. med.) der Medizinischen Fakultät der Universität Ulm vorgelegt von Marcel Werner Stahl geb. in Esslingen a. N. 2010 Amtierender Dekan: Prof. Dr. Thomas Wirth 1. Berichterstatter: Prof. Dr. M. Otto 2. Berichterstatter: Prof. Dr. T. Böckers Tag der Promotion: 08.12.2011 Meinen geliebten Eltern, in tiefer Dankbarkeit gewidmet. Index of contents Index of contents List of abbreviations VII 1 Introduction ................................................................................................................... 1 1.1 Historical approach to the prion protein ................................ 1 C1.2 The physiological function of PrP ....................................... 6 1.3 Caenorhabditis elegans ....................................................... 16 1.4 Objective of this work ......................................................... 20 2 Material and methods .................................................................. 21 2.1 Material ................................................ 21 2.2 Methods ...................................