Characterization of CD133-positive cells in stem cell regions of the developing and adult murine central nervous system [Elektronische Ressource] / vorgelegt von Cosima Pfenninger

Characterization of CD133-positive cells in stem cell regions of the developing and adult murine central nervous system vorgelegt von Diplom-Ingenieurin Cosima Viola Pfenninger aus Erlangen Von der Fakultät III – Prozesswissenschaften der Technischen Universität Berlin zur Erlangung des akademischen Grades Doktorin der Naturwissenschaften – Dr. rer. nat. – genehmigte Dissertation Promotionsausschuss: Vorsitzender: Prof. Dr. Peter Neubauer Berichter: Prof. Dr. Roland Lauster rof. Dr. Ulrike Nuber Tag der wissenschaftlichen Aussprache: 11.12. 2009 Berlin 2010 D 83 Table of Content................................................................................................................ I Abbreviations..................................................................................................................... IV 1. Introduction................................................................................................................... 1 1.1 Definition of stem and progenitor cells..................................................................... 1 1.2 In vitro neural stem/progenitor cell assay.................................................................. 1 1.3 Stem and progenitor cells in the murine central nervous system.............................. 2 1.3.1 Neural stem and progenitor cells in the developing forebrain.......................... 2 1.3.