Characterization of Candida albicans genes involved in cell wall biogenesis and infection [Elektronische Ressource] / vorgelegt von Martin Zavrel

Characterization of Candida albicans Genes Involved in Cell Wall Biogenesis and Infection Von der Fakultät Energie-, Verfahrens- und Biotechnik der Universität Stuttgart zur Erlangung der Würde eines Doktors der Naturwissenschaften (Dr. rer. nat.) genehmigte Abhandlung Vorgelegt von Martin Zavrel aus Usti nad Labem (CZ) Hauptberichter: Prof. Dr. H. Brunner Mitberichter: Prof. Dr. D. Wolf Tag der mündlichen Prüfung: 27. 10. 2010 Institut für Grenzflächenverfahrenstechnik der Universität Stuttgart 2010 I hereby declare that this submission is my own work and that, to the best of my knowledge and belief, it contains no material previously published or written by another person. Materials of work found by other researcher are mentioned by reference. This thesis, neither in whole nor in part, has been previously submitted for any degree. Stuttgart, June 2010 Martin Zavrel TABLE OF CONTENTS 1 SUMMARY V ZUSAMMENFASSUNG VII 2 LIST OF ABBREVIATIONS IX 2.1 Standard Abbreviations IX 2.2 Gene Abbreviations XI 3 INTRODUCTION 1 3.1 Introduction to Candida albicans 1 3.2 Candidal Infections 2 3.3 Hypha Formation 4 3.3.1 Transcription Factors Efg1 and Cph1 6 3.4 Cell Wall of Candida albicans 7 3.4.1 GPI Anchored Proteins - PGAs 9 3.5 Adhesion 10 3.5.